Pharmacokinetics

Pharmacokinetics is often summarised as ADME. What does ADME stand for?

1. Absorption, dosage, monitoring and elimination
2. Absorption, distribution, metabolism and excretion
3. Action, dose, mechanism and effect
4. Administration, dissolution, metabolism and efficacy

What is the bioavailability of a drug given intravenously?

1. It depends on food
2. 0%
3. 50%
4. 100%

First-pass metabolism mainly takes place in the:

1. Kidneys
2. Skin
3. Lungs
4. Liver

The half-life of a drug is:

1. The time taken for its plasma concentration to fall by half
2. Half its duration of action
3. Half the time it takes to work
4. The time it takes to be absorbed

With regular dosing, steady state is reached after about:

1. 10 to 12 half-lives
2. 4 to 5 half-lives
3. 2 days, for every drug
4. 1 half-life

A drug has a half-life of 6 hours. What fraction remains 24 hours after a single dose?

1. 1/24
2. 1/16
3. 1/4
4. 1/8

The apparent volume of distribution is:

1. The volume of the blood
2. The volume of the tablet
3. The dose divided by the plasma concentration
4. The volume of urine produced